摘要
缺血性心脏病(IHD)是一种发病率和致死率均较高的心血管疾病,严重威胁人类健康。随着宏基因组测序和16S rRNA技术的普遍应用,肠道菌群与IHD的关系逐渐被揭示。“肠-心”轴理论的提出,为研究肠道菌群与IHD风险因素的相关性及相互作用提供了新方向。肠道菌群丰度的变化和肠道菌群的代谢产物均可促进IHD风险因素的发生,从而影响IHD患者的病情进展与预后。因此,深入研究肠道菌群与IHD的相关性或可为疾病的治疗提供新思路。
Ischemic heart disease(IHD)is a cardiovascular disease with a high incidence and mortality rate,which is a serious threat to human health.With the common application of macrogenome sequencing and 16S rRNA technology,the relationship between intestinal microbiota and IHD has been gradually revealed.The proposed"gut-heart"axis provides a direction to study the correlation and interaction between intestinal microbiota and IHD risk factors.Changes in the abundance and the metabolites of intestinal microbiota can contribute to the development of IHD risk factors,thus affecting the disease progression and prognosis.Therefore,an in-depth study of the correlation between intestinal microbiota and IHD may provide new ideas for the treatment of the disease.
作者
薛志鹏
周慧慧
杜少兵
李菁
孟祎
白吉庆
王小平
XUE Zhipeng;ZHOU Huihui;DU Shaobing;LI Jing;MENG Yi;BAI Jiqing;WANG Xiaoping(College of Pharmacy,Shaanxi University of Chinese Medicine,Xianyang 712046,China;Shaanxi Key Lab of Chinese Medicine Fundamentals and New Drugs Research,Xianyang 712046,China)
出处
《医学综述》
CAS
2023年第7期1404-1408,共5页
Medical Recapitulate
基金
国家自然科学基金(81974544)。
关键词
缺血性心脏病
肠道菌群
“肠-心”轴
风险因素
Ischemic heart disease
Intestinal microbiota
"Gut-heart"axis
Risk factors
