血清炎症因子与支气管哮喘气道重构相关性的研究进展

Research Progress in Relationship between Serological Indexes and Airway Remodeling in Bronchial Asthma

支气管哮喘是临床较常见的呼吸系统疾病,主要临床特征为气道炎症、气道高反应性以及气道重构。其中,气道重构提示气道已产生不可逆性结构异变,严重影响患者呼吸系统的正常运作。而气道重构与患者血清中白细胞介素-13、基质金属蛋白酶9以及肿瘤坏死因子-α等炎症因子的表达密切相关。因此,未来深入研究血清炎症因子与支气管哮喘气道重构的相关性,可以有针对性地制订个性化治疗方案,以治愈疾病、改善患者预后。

Bronchial asthma is a common respiratory disease in clinic.Its main clinical features are airway inflammation,airway hyperresponsiveness and airway remodeling.Among them,airway remodeling indicates that the airway has produced irreversible structural changes,which seriously affects the normal operation of the patient′s respiratory system.Airway remodeling is closely related to the expression of inflammatory factors such as serum interleukin-13,matrix metalloproteinase-9 and tumor necrosis factor-α.Therefore,in the future,in-depth study of the correlation between serum inflammatory factors and airway remodeling of bronchial asthma can help to formulate individualized treatment plans,cure the disease and improve the prognosis of the patients.