摘要
MEOX2基因属于同源异型盒转录因子家族,与大量信号转导通路有关,是细胞分化、血管生成及胚胎发育等的重要调控基因。MEOX2基因的表达异常与喉癌、肾母细胞瘤等恶性肿瘤的发生发展及淋巴结转移有关,但在乳腺癌、非小细胞肺癌等恶性肿瘤中,不同的研究得出的结论不同,有的认为其在肿瘤的发生发展中起抑制作用,有的则发现其促进肿瘤的发生发展。因此,为了明确MEOX2基因在恶性肿瘤中的具体作用,需要采用新的研究方法,或加大样本量,进行多角度、多中心的研究。
Mesenchyme homeobox 2(MEOX2)gene belongs to the homeobox transcription factor family,which is associated with a large number of signal transduction pathways and is an important regulator of cell differentiation,angiogenesis and embryo development.The abnormal expression of MEOX2 gene is associated with the occurrence,development and metastasis of malignant tumors such as laryngeal cancer and nephroblastoma.However,in the study of breast cancer,non-small cell lung cancer and other malignant tumors,different studies have drawn different conclusions,some believe that it plays an inhibitory role in the occurrence and development of tumors,and some find that it promotes the occurrence and development of tumors.Therefore,in order to clarify the role of MEOX2 gene in malignant tumors,it is necessary to adopt new research methods,or increase the sample size,and further conduct multi-angle and multi-center studies.
作者
白杨
曾婧
王大维
BAI Yang;ZENG Jing;WANG Dawei(Department of Oral and Maxillofacial Surgery,the Third Hospital of Hebei Medical University,Shijiazhuang 050051,China)
出处
《医学综述》
CAS
2023年第8期1521-1526,共6页
Medical Recapitulate
基金
河北省政府资助临床医学优秀人才培养项目(冀财预复〔2020〕397号)。
关键词
恶性肿瘤
MEOX2
同源异型盒基因家族
转录因子
Malignant tumor
Mesenchyme homeobox 2
Homeobox gene family
Transcription factors