阴道上皮内瘤变治疗的研究进展

Research Progress in Treatment of Vaginal Intraepithelial Neoplasia

阴道上皮内瘤变(VaIN)是一组发病率较低的疾病,是阴道浸润性癌的癌前病变,其发生与人乳头瘤病毒感染密切相关。VaIN患者通常无特征性的临床症状,仅有少数患者有阴道出血或阴道分泌物异常的表现。目前临床治疗VaIN的方法主要有保守治疗、药物治疗、物理治疗、手术治疗和放疗,不同的治疗方法各有其优缺点。在临床上,VaIN的治疗常根据患者的实际情况进行个体化治疗。但目前有关这方面的研究较少、样本量较小,且国际上尚无公认的治疗指南,仍需要进行深入研究,以期为VaIN的治疗提供新思路。

Vaginal intraepithelial neoplasia(VaIN)is a group of diseases with low incidence rate,which is a precancerous lesion of invasive carcinoma of vagina,and its occurrence is closely related to human papilloma virus infection.VaIN patients usually have no characteristic clinical symptoms,and only a few patients have vaginal bleeding or abnormal vaginal discharge.At present,the clinical treatment methods for VaIN mainly include conservative management,drug therapy,physical therapy,surgery and radiotherapy.Different treatment methods have their advantages and disadvantages.In clinical practice,the treatment of VaIN is often individualized based on the actual situation of the patient.However,at present,there are few studies on this aspect,the sample size is small,and there is no recognized treatment guideline in the world,so further studies are still needed to provide new ideas for the treatment of VaIN.