血清标志物在儿童中枢神经系统感染鉴别诊断中的研究进展

Research Progress of Serum Markers in Differential Diagnosis of Infection of Central Nervous System in Children

儿童中枢神经系统感染(ICNS)是新生儿科常见疾病,由于儿童的血脑屏障发育暂不完善,极易受到细菌、病毒等各类病原体侵犯,导致脑实质、脑膜等部位发生炎性、非炎性疾病。若未能及时诊治,可引发脑积水、脓肿等,严重者可危及患儿生命。现阶段,临床鉴别诊断ICNS的常用方法为血清学、脑脊液检查,但儿童依从性普遍较差,脑脊液检查危险性高;而血清标志物检测操作简便、对儿童造成的痛苦较小且安全性高,是临床鉴别诊断各类疾病的常用检测方式。因此,寻找有效、准确鉴别诊断儿童ICNS的血清学指标十分重要。

Infection of central nervous system(ICNS)in children is a common disease in neonatology.Due to the incomplete development of blood-brain barrier in children,they are extremely susceptible to invasion by various pathogens such as bacteria and viruses,resulting in inflammatory and non-inflammatory diseases in brain parenchyma,meninges and other parts.If not diagnosed and treated in time,it can cause hydrocephalus,abscess,etc.,which can endanger the life of children in severe cases.At present,the common methods of clinical differential diagnosis of ICNS are serology and cerebrospinal fluid examination,but the compliance of children is generally low and the risk of cerebrospinal fluid examination is high.The detection of serum markers is simple,less painful and safe for children,and is a common detection method for clinical differential diagnosis of various diseases.Therefore,it is very important to seek effective and accurate serological indicators for differential diagnosis of ICNS in children.