辐射对巨噬细胞极化和功能的调节作用

A review of regulatory effects of radiation on the polarization and functions of macrophages

巨噬细胞是存在于所有组织中的调节性细胞,它们对辐射刺激的反应机制复杂,既有共同的应对感染、损伤的变化过程,也有自己独特的极化转变方式。辐射相关的极化转变决定了巨噬细胞的功能类型。巨噬细胞受到不同的照射后,受到不同细胞因子的调节,涉及多个信号通路,极化程度也有所不同。本文综述辐射对巨噬细胞极化和功能的调节作用,以期对免疫基础研究和临床放射治疗提供参考。

Macrophages,as regulatory cells existing in all tissues,exhibit complex responses to radiation stimulation,including both common processes in response to infection and injury and unique polarization transformation.Radiation-related polarization determines the functional types of macrophages.After being exposed to different irradiations,macrophages are regulated by different cytokines,involving multiple signaling pathways.This leads to differential degrees of polarization.The review summarized the regulatory effects of radiation on the polarization and functions of macrophages in order to provide basis for theoretical research on immunity and clinical radiotherapy.