TBC1结构域家族成员4与心肌胰岛素抵抗的研究进展

Research Progress of TBC1 Domain Family Member 4 and Myocardial Insulin Resistance

体外循环是心血管外科开胸心内直视手术必需的重要辅助手段,而体外循环术后常见的严重并发症是心肌缺血再灌注损伤(MIRI)。MIRI的发生机制复杂,心肌胰岛素抵抗(IR)是其重要发病机制之一,其中心肌细胞葡萄糖转运蛋白4(GLUT4)的表达和转位异常是心肌IR发生的主要原因。TBC1结构域家族成员4是TBC家族蛋白的重要成员,可通过Rab蛋白调控GLUT4的囊泡转运,是磷脂酰肌醇-3-激酶/蛋白激酶B信号通路和AMP活化的蛋白激酶信号通路重要的下游靶点,与IR的发生密切相关。

Cardiopulmonary bypass is a necessary auxiliary technique for intracardiac operation under direct vision in cardiovascular surgery,and myocardial ischemia-reperfusion injury(MIRI)is the common serious complication after cardiopulmonary bypass.The mechanism of MIRI is complicated,and myocardial insulin resistance(IR)is one of the important pathogeneses of MIRI.Abnormal expression and translocation of glucose transporter 4(GLUT4)in cardiomyocytes are the main causes of myocardial IR.TBC1 domain family member 4 is an important member of TBC family protein,which can regulate the GLUT4 vesicles transport through Rab proteins.It is an important downstream target of phosphatidylinositol-3-kinase/protein kinase B signaling pathway and AMP activated protein kinase signaling pathway,and is closely associated with the development of IR.