摘要
脑出血是脑内血管破裂后血液外溢对脑实质产生损害的一类疾病,死亡率、致残率高,是神经内科的急症。脑出血后脑损伤涉及多种机制,其损伤程度决定了患者的预后。而脑出血的内科治疗方法相对局限,近年发现,经典炎症因子核因子κB(NF-κB)在脑出血后激活并参与脑损伤的形成和发展,通过调控NF-κB缓解脑出血后脑损伤的发生发展,但目前均处于动物实验阶段。未来可在此基础上开展更高质量的临床试验,以为脑出血的治疗提供新思路。
Cerebral hemorrhage is a type of disease that causes damage to the brain parenchyma due to the overflow of blood after the rupture of cerebral blood vessels.It has a high mortality and disability rate and is an emergency in neurology.The brain injury after cerebral hemorrhage involves multiple mechanisms,and injury degree determines the prognosis of the patients.However,the medical treatment methods for cerebral hemorrhage are relatively limited.In recent years,it has been discovered that the classic inflammatory factor nuclear factor-κB(NF-κB)is activated and participates in the formation and development of brain injury after cerebral hemorrhage,and regulating NF-κB alleviates the occurrence and development of brain injury after cerebral hemorrhage,but it is currently in the animal experimental stage.In the future,higher quality clinical trials can be conducted on this basis to provide new therapeutic ideas for cerebral hemorrhage.
作者
高小姗
谷有全
雒扬
张逸轩
GAO Xiaoshan;GU Youquan;LUO Yang;ZHANG Yixuan(The First School of Clinical Medicine of Lanzhou University,Lanzhou 730000,China;Department of Neurology,the First Hospital of Lanzhou University,Lanzhou 730000,China)
出处
《医学综述》
CAS
2023年第13期2532-2536,共5页
Medical Recapitulate
关键词
脑出血
脑损伤
核因子ΚB
Cerebral hemorrhage
Brain injury
Nuclear factor-κB