脊髓损伤后神经源性肠道功能障碍的治疗进展

Advances in Treatment of Neurogenic Bowel Dysfunction after Spinal Cord Injury

神经源性肠道功能障碍(NBD)是脊髓损伤后常见的并发症之一,其发生与神经调节紊乱、神经递质含量变化、肠神经系统障碍、肠道微生物变化等因素相关,临床表现主要为便秘、大便失禁、排便困难等,使患者生活质量严重下降,甚至可能诱发心理障碍。因此,NBD的治疗越来越受到临床重视,其治疗方法多样,目前国内外临床研究以药物、灌肠、电刺激、手术等治疗方法为主,但均存在优势及不足,而我国特有的中医疗法为脊髓损伤后NBD提供了新的治疗思路。

Neurogenic bowel dysfunction(NBD)is one of the common complications after spinal cord injury,and its occurrence is related to factors such as neuromodulation disorders,changes in neurotransmitters contents,enteric nervous system disorders and intestinal microbial changes.The main clinical manifestations of NBD are constipation,fecal incontinence and defecation difficulty,seriously reducing the quality of life of the patients,and may even induce psychological disorders.Therefore,the treatment of NBD has received more and more clinical attention,and its treatment methods are diverse.At present,drugs,enema,electrical stimulation and surgery are the main treatment methods in clinical research at home and abroad,but the above methods all have their own advantages and disadvantages.The unique traditional Chinese medicine therapies in China provide new treatment ideas for NBD after spinal cord injury.