贫血对晚期胃癌患者预后及生活质量的影响

Influence of Anemia on the Prognosis and Quality of Life of Patients with Advanced Gastric Cancer

目的:探讨贫血对晚期胃癌患者预后及生活质量的影响。方法:依据晚期胃癌患者入组时基线血红蛋白值将其分为轻度贫血组、中重度贫血组与非贫血组,通过晚期胃癌患者中位生存时间观察贫血对患者预后的影响;将晚期胃癌患者根据中药干预时间,以3个月为界,分为足量暴露组(3个月以上)和非足量暴露组(不足3个月),分析中药暴露对晚期胃癌贫血患者预后的影响;采用《肿瘤常见症状及中医症状调查表》评估晚期胃癌患者症状及其生活质量。结果:贫血与晚期胃癌患者生活质量和生存预后呈负相关;相较于非贫血患者,肿瘤合并贫血患者具有预后不良、临床症状严重、生活质量差等特点。结论:中医药可能通过提高患者血红蛋白水平来改善患者预后。

Objective:To discuss the influence of anemia on the prognosis and quality of life of patients with advanced gastric cancer.Methods:The patients with advanced gastric cancer were divided into mild anaemia group,moderate to severe anaemia group and non-anaemia group according to the baseline hemoglobin values at enrolment,to observe the effects of anemia on the prognosis of the patients by their median survival time;according to the intervention time of TCM,the patients,based on a three-month period,were separated into full exposure group(longer than three months)and non-fully exposed group(less than three months),to analyze the impacts of TCM exposure on the prognosis of the patients;questionnaire on common symptoms of tumor and TCM symptoms was adopted to assess the influence of symptoms on the patients’quality of life.Results:Anemia was negatively associated with quality of life and survival prognosis in gastric cancer patients;compared with nonanemia patients,the patients with tumor and anemia showed the characteristics of poor prognosis,severe clinical symptoms and poor quality of life.Conclusion:TCM could improve the prognosis possibly through raising the levels of hemoglobin.