益气化痰通络方对气虚痰瘀证sICAS患者内皮素和一氧化氮水平的影响

Influence of Benefiting-Qi Phlegm-resolving Collateral-dredging Prescription on the Levels of Endothelin and Nitric Oxide in Patients with sICAS of Qi-deficiency and Phlegm-stagnation Pattern

目的:观察益气化痰通络方对症状性动脉粥样硬化性颅内动脉狭窄(symptomatic intracranial atherosclerotic stenosis,sICAS)气虚痰瘀证患者血浆内皮素1(endothelin,ET-1)和一氧化氮(nitric oxide,NO)水平的影响。方法:将23例sICAS气虚痰瘀证患者随机分为安慰剂组10例与治疗组13例。两组患者均针对高血压病、糖尿病、血脂异常、冠心病、吸烟等危险因素进行干预治疗。在西医常规治疗的基础上治疗组加益气化痰通络方治疗,安慰剂组加安慰剂颗粒。观察两组患者干预前及干预3个月血清NO和ET-1水平。结果:干预后两组患者NO水平较干预前升高(P<0.05),ET-1水平较干预前降低(P<0.05);与安慰剂组干预后比较,治疗组NO水平升高,ET水平降低(P<0.05)。结论:在西医常规治疗的基础上加用益气化痰通络方改善sICAS气虚痰瘀证患者血管内皮功能效果更明显。

Objective:To observe the effects of benefiting-Qi phlegm-resolving collateral-dredging prescription on the levels of endothelin-1(ET-1)and nitric oxide(NO)in patients with symptomatic intracranial atherosclerotic stenosis(sICAS)of Qi deficiency and phlegm-stagnation pattern.Methods:All 23 patients were randomized into 10 cases in the placebo-controlled group and 13 cases of the treatment group.Both groups accepted the intervention for risk factors such as hypertension,diabetes mellitus,dyslipidaemia,coronary heart disease,smoking,etc.Based on routine therapy of Western medicine,the treatment group was treated with benefiting-Qi phlegm-resolving collateral-dredging prescription,the placebo-controlled group took the granules of placebo.To observe the levels of ET-1 and NO before the intervention between both groups and after three months of the intervention.Results:After the intervention,the levels of NO in both groups were raised than before the intervention(P<0.05),the levels of ET-1 were decreased than before the intervention(P<0.05);compared with the placebo-controlled group after the intervention,the levels of NO were lifted while the levels of ET-1 were reduced in the treatment group(P<0.05).Conclusion:Based on the routine therapy of Western medicine,the addition of benefiting-Qi phlegm-resolving collateral-dredging prescription could improve vascular endothelial function of the patients.