心理、社会、医源性因素与育龄女性卵巢早衰的相关性

Psychological,Social,and Iatrogenic Factors Associated with Premature Ovarian Failure in Reproductive-Age Women

【目的】探讨心理、社会、医源性因素与育龄女性卵巢早衰(POF)的相关性。【方法】回顾性分析2019年1月至2021年1月西安市妇幼保健院收治的80例POF患者的临床资料(观察组),选取同期于本院进行健康体检的127例健康女性作为对照组。比较两组研究对象的一般资料,采用多因素Logistic回归分析影响育龄女性POF的危险因素,Pearson系数分析POF与相关因素的相关性。【结果】观察组社交焦虑量表(ASA)评分、贝克抑郁量表(BDI)评分及卵巢手术史、盆腔手术史、避孕药物应用所占比例显著高于对照组,差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,社交焦虑、抑郁、卵巢手术史、盆腔手术史、避孕药物应用是育龄女性POF的危险因素(P<0.05)。Pearson相关性分析显示,育龄女性POF与社交焦虑、抑郁、卵巢手术史、盆腔手术史、避孕药物应用均呈正相关(P<0.05)。受试者工作特征曲线分析结果显示,社交焦虑、抑郁、卵巢手术史、盆腔手术史、避孕药物应用情况均具有较高的预测效能,曲线下面积分别为0.821、0.871、0.561、0.634、0.613。【结论】育龄女性POF的发病与社交焦虑、抑郁、卵巢手术史、盆腔手术史等因素有关,临床医务工作者需从病因入手,制定合理的治疗方案,进而改善育龄女性POF患者的生殖健康和生活质量。

【Objective】To investigate the correlation between premature ovarian failure(POF)and psychological,social,and iatrogenic factors in reproductive-age women.【Methods】A retrospective analysis was conducted on the clinical data of 80 POF patients admitted to the Xi'an Maternal and Child Health Hospital from January 2019 to January 2021(observation group),and 127 healthy women who underwent health examination in the same period were selected as the control group.General information was compared between the two groups,and multiple factor logistic regression analysis was used to identify risk factors for POF in reproductive-age women.Pearson correlation analysis was used to analyze the correlation between POF and related factors.【Results】The observation group had significantly higher scores on the Social Anxiety Scale(ASA)and Beck Depression Inventory(BDI),as well as a higher proportion of ovarian surgery history,pelvic surgery history,and use of contraceptives compared to the control group(P<0.05).Multivariate logistic regression analysis showed that social anxiety,depression,ovarian surgery history,pelvic surgery history,and use of contraceptives were risk factors for POF in reproductive-age women(P<0.05).Pearson correlation analysis showed a positive correlation between POF and social anxiety,depression,ovarian surgery history,pelvic surgery history,and use of contraceptives in reproductive-age women(P<0.05).Analysis of the receiver operating characteristic curve showed that social anxiety,depression,ovarian surgery history,pelvic surgery history,and use of contraceptives had high predictive efficiency,with area under the curve of 0.821,0.871,0.561,0.634,and 0.613,respectively.【Conclusion】The incidence of POF in reproductive-age women is related to factors such as social anxiety,depression,ovarian surgery history,pelvic surgery history,etc.Clinical medical workers need to start with the etiology to develop reasonable treatment plans and thereby improve the reproductive health and quality of life of POF patients in reproductive-age women.