活性氧调控血小板功能的研究进展

Research Progress in Reactive Oxygen Species Regulation of Platelet Function

活性氧是一种重要的氧反应元件,在氧化还原反应中居重要地位。血小板是人体内最小的一种血细胞,在生理性止血和病理性血栓形成中发挥着重要作用。活化的血小板可以通过细胞膜酶复合物还原烟酰胺腺嘌呤磷酸二核苷酸催化反应和线粒体电子传递链反应产生大量活性氧。内源性和外源性的活性氧可以通过调节血小板受体、改变血小板激动剂或抑制剂的生物利用度、促进异前列素形成以及氧化低密度脂蛋白途径影响血小板的活化。氧化还原反应与氧化应激之间的相互平衡可以调控血小板功能、抑制血栓形成。深入研究活性氧在血小板活化和功能中的调控作用,有望为心血管疾病、血栓性疾病的治疗提供新途径。

Reactive oxygen species is an important oxygen reaction element and plays an important role in redox reactions.Platelets are the smallest blood cells in the human body,which play important roles in physiologic hemostasis and pathological thrombosis.Activated platelets can generate a large amount of reactive oxygen species through catalytic reaction of reducing nicotinamide adenine phosphate dinucleotide and mitochondrial electron transfer chain reactions.Endogenous and exogenous reactive oxygen species can affect platelet activation by regulating platelet receptors,altering the bioavailability of platelet agonists or inhibitors,promoting isoprost formation,and oxidizing low density lipoprotein pathways.The balance between oxidative stress and redox state can regulate plate function and inhibit thrombosis.An in-depth study of reactive oxygen species role in the regulation of platelet activation and function is expected to provide new clues for the treatment of cardiovascular and thrombotic diseases.