同型半胱氨酸与非酒精性脂肪性肝病的相关性及发病机制研究进展

Research Progress of Correlation between Homocysteine and Non-alcoholic Fatty Liver Disease and Related Pathogenesis

非酒精性脂肪性肝病(NAFLD)的发病率逐年升高,是全球最常见的慢性肝病,在临床上常与糖尿病、心血管疾病并存,其具体发病机制目前尚未明确。同型半胱氨酸(Hcy)是糖尿病、心血管疾病的独立危险因素,NAFLD患者血浆Hcy水平显著升高,但其严重程度与Hcy的关系目前尚无定论。此外,Hcy在胰岛素抵抗、氧化应激、内质网应激与脂质代谢等过程中也发挥重要作用,与NAFLD的发生发展密切相关。因此,未来深入研究Hcy与NAFLD的关系对于NAFLD的早期防治具有重要意义。

The incidence rate of non-alcoholic fatty liver disease(NAFLD)is increasing year by year.It is the most common chronic liver disease in the world,which often coexists with diabetes and cardiovascular disease clinically,but its specific pathogenesis is not yet clear.Homocysteine(Hcy)is an independent risk factor for diabetes and cardiovascular disease.Plasma Hcy levels in NAFLD patients are significantly higher,but the relationship between its severity and Hcy is still uncertain.In addition,Hcy also plays an important role in insulin resistance,oxidative stress,endoplasmic reticulum stress and lipid metabolism,which is closely related to the occurrence and development of NAFLD.Therefore,further research on the relationship between Hcy and NAFLD in the future is of great significance for the early prevention and treatment of NAFLD.