炎症信号通路与慢加急性肝衰竭关系的研究进展

Research Progress of Correlations between Inflammatory Signaling Pathways and Acute-on-chronic Liver Failure

慢加急性肝衰竭(ACLF)是在既往慢性肝病基础上遭受“二次打击”所致,也是临床肝脏危重症,其病情恶化速度快、病死率高。肝脏炎症是ACLF的显著特点,在ACLF的发展中发挥重要作用,而乙型肝炎病毒感染引起的慢性乙型肝炎是ACLF的主要原因之一。核因子κB、促分裂原活化的蛋白激酶、胱天蛋白酶等信号通路参与炎症调控,与肝炎后ACLF的发生发展密切相关,这些炎症信号通路的磷酸化激活或表达水平变化可影响ACLF进展。因此,深入研究炎症信号通路与ACLF的关系,可以为疾病的治疗提供新思路。

Acute-on-chronic liver failure(ACLF)is caused by"second strike"on the basis of previous chronic liver disease,which is a clinical critical liver disease with rapid deterioration and high mortality.Liver inflammation is a significant feature and plays an important role in the development of ACLF,while chronic hepatitis B caused by hepatitis B virus infection is one of the main causes of ACLF.Nuclear factor-κB,mitogen-activated protein kinase,caspase signaling pathways are involved in inflammatory regulation,which are closely related to the occurrence and development of ACLF after hepatitis,and the phosphorylation activation or changes in expression levels of these inflammatory signaling pathways may affect the development of ACLF.Therefore,the deeper study of the relationship between inflammatory signaling pathways and ACLF may provide new ideas for the treatment of the diseases.