神经干细胞移植修复脊髓损伤的研究进展

Research Progress of Neural Stem Cells Transplantation in Repairing Spinal Cord Injury

脊髓损伤(SCI)是一种高发病率、高致残率、高致死率的疾病,可导致患者感觉与运动功能丧失。修复SCI的关键在于在损伤部位再生足够数量有功能的神经元,重建神经网络,恢复缺失的功能。神经干细胞(NSCs)移植技术在神经系统疾病的治疗中具有独特优势,可在损伤轴突与靶神经元之间再生新神经元并重新建立信号连接。SCI后的抑制性微环境可导致NSCs分化为胶质细胞,而正确调控NSCs分化方向、诱导其分化为神经元,可以为临床SCI修复提供新思路。

Spinal cord injury(SCI)is a disease with high incidence,high disability and high mortality,which can lead to the loss of sensory and motor function of the patients.The key to repair SCI is to regenerate a sufficient number of functional neurons at the injury site,so as to reconstruct the neural network to restore the incomplete function.Neural stem cells(NSCs)transplantation technology has unique advantages in the treatment of neurological diseases.It can regenerate new neurons and re-establish signal connections between injured axons and target neurons.However,the inhibitory microenvironment after SCI can make NSCs differentiate into glial cells.Therefore,correct regulation of the differentiation direction of NSCs and inducing them to differentiate into neurons can provide new ideas for clinical SCI repair.