妊娠期高血压综合征患者降压药物应用研究进展

Research Progress in Application of Antihypertensive Drugs in Patients with Hypertensive Disorders in Pregnancy

妊娠期高血压综合征(HDP)是妊娠期特有的严重疾病,极易诱发以血管病变为基础的脏器损伤,危及母婴生命安全,目前仍以药物干预为主。随着对抗高血压治疗的不断研究,HDP患者的临床疗效、妊娠结局等均获得较大改善。但由于HDP患者生理特殊性,临床对HDP防治规范不统一且患者存在个体差异,导致临床疗效及预后差异较大。而药物方案的选择可直接影响HDP患者妊娠结局、新生儿生存率。因此,早期明确不同种类降压药物在HDP中的效果,对如何为所有患者制订最佳药物治疗方案极具参考意义,且有望为提高HDP的临床疗效提供新靶点。

Hypertensive disorders in pregnancy(HDP)is a serious disease peculiar to pregnancy,which can easily induce organ damage based on vascular lesions and endanger the safety of mother and child.At present,drug intervention is still the main treatment.With the continuous research on antihypertensive treatment,the clinical efficacy and pregnancy outcomes of HDP patients have been greatly improved.However,due to the physiological particularity of HDP patients,the clinical prevention and treatment of HDP is not uniform,and there are individual differences in patients,resulting in great differences of the clinical efficacy and prognosis.The choice of drug regimen can directly affect the pregnancy outcome and neonatal survival rate of HDP patients.Therefore,early identification of the effects of different kinds of antihypertensive drugs in HDP is of great reference significance for formulating the optimal drug treatment plan for all the patients,and is expected to provide new targets for improving the clinical effect for HDP.