摘要
高原肺水肿(HAPE)是严重危及生命的重症急性高原病之一。在高海拔地区低氧低压环境下,患者肺血管收缩、肺血管压力升高,在血管活性物质、炎症因子、神经内分泌等机制共同参与下,最终导致HAPE发生。此外,遗传因素也可能与HAPE易感性增加有关,在基因、转录、表观遗传等不同水平存在多种与遗传易感性相关的因素。因此,未来深入研究HAPE的发病机制,有助于筛查HAPE易感人群、优化HAPE防治策略,为HAPE患者的治疗提供新思路。
High altitude pulmonary edema(HAPE)is one of the severe acute altitude diseases.In the hypoxygen hypobaric environment at high altitude,pulmonary vasoconstriction and increased pulmonary vascular pressure,with the participation of vasoactive substances,inflammatory factors,neuroendocrine and other mechanisms,ultimately lead to HAPE.In addition,genetic factors may be associated with increased susceptibility to HAPE.There are multiple factors related to genetic susceptibility at different levels,such as genes,transcription and epigenetics.Therefore,further research on the pathogenesis of HAPE will help to screen the population susceptible to HAPE,optimize the prevention and treatment strategy of HAPE,and provide new ideas for the treatment of HAPE.
作者
韩俊丽
王俩合
雷晓佳
聂梅
杜宣运
次仁央宗
白玛德吉
HAN Junli;WANG Lianghe;LEI Xiaojia;NIE Mei;DU Xuanyun;CIREN Yangzong;BAIMA Deji(Department of Critical Care Medicine,the Second Affiliated Hospital,Xi′an Jiaotong University,Xi′an 710004,China;Department of Critical Care Medicine,Ngari Prefecture People′s Hospital,Ngari 859000,China;Department of Internal Medicine,Ngari Prefecture People′s Hospital,Ngari 859000,China;Department of Clinical Laboratory,Ngari Prefecture People′s Hospital,Ngari 859000,China;Department of Ultrasound,Ngari Prefecture People′s Hospital,Ngari 859000,China)
出处
《医学综述》
CAS
2023年第17期3352-3357,共6页
Medical Recapitulate
基金
西藏自治区自然科学基金组团式医学援藏项目(XZ2019ZR-ZY73(Z))
陕西省重点研发计划项目(2021SF-256)。
关键词
高原肺水肿
急性高原病
肺血管
High altitude pulmonary edema
Acute mountain sickness
Pulmonary vessles