摘要
胃癌是常见的消化道恶性肿瘤,严重威胁患者生命。近年来,随着非编码RNA(ncRNA)甲基化修饰在胃癌中的研究发现,ncRNA甲基化修饰影响细胞分化、血管生成、免疫反应、炎症反应等阶段,进而参与胃癌的发生发展、分化、侵袭转移及转归预后等环节。此外,ncRNA甲基化修饰具备差异性表达的特点,可以通过联合检测构建胃癌诊断和预后模型,具有成为胃癌分子标志物的巨大潜能。深入研究甲基化修饰的机制和表达特点,发掘分子生物学应用于胃癌的临床价值,可为胃癌的诊疗提供新思路。
Gastric cancer is a common malignant tumor of digestive system,seriously threatening the patients′lives.In recent years,with the development of studies on non-coding RNA(ncRNA)methylation in gastric cancer,researchers have found that ncRNA methylation affects cell differentiation,angiogenesis,immune response,inflammation and other phases.And ncRNA methylation is further involved in the development,differentiation,invasion,metastasis,prognosis and other processes.And ncRNA methylation modification has the characteristics of differential expression,which can be used to construct a diagnosis and prognosis model of gastric cancer through combined detection,and has great potential to become a molecular marker of gastric cancer.Further study on the mechanism and expression characteristics of methylation modification and exploring the clinical value of molecular biology in gastric cancer can provide new ideas for the diagnosis and treatment of gastric cancer.
作者
赵乔飞
查文章
周勇
张业鹏
ZHAO Qiaofei;ZHA Wenzhang;ZHOU Yong;ZHANG Yepeng(The Yancheng Clinical College of Xuzhou Medical University,Yancheng 224000,China;Department of General Surgery,Yancheng NO.1 People′s Hospital,Yancheng 224000,China;Department of General Surgery,the Fourth Affiliated Hospital of Nantong University,Yancheng 224000,China)
出处
《医学综述》
CAS
2023年第17期3389-3393,3399,共6页
Medical Recapitulate
基金
江苏省卫生健康委员会医学科研面上项目(M2020100)。
关键词
胃癌
非编码RNA
甲基化修饰
Gastric cancer
Non-coding RNA
Methylation modification
