皮质类固醇鼻腔冲洗在慢性鼻窦炎中的应用进展

Progress in Application of Corticosteroid Nasal Irrigation in Chronic Rhinosinusitis

慢性鼻窦炎(CRS)是鼻黏膜和鼻窦的一种慢性炎症性疾病,对患者的生活质量造成严重影响。对于大多数CRS患者,鼻用皮质类固醇作为药物治疗的最主要治疗手段同内镜鼻窦手术共同参与CRS的多模式综合治疗。但鼻用皮质类固醇最佳给药方式及如何达到最佳疗效目前尚无定论。近年来,国内外对CRS皮质类固醇鼻腔冲洗局部治疗方式进行了研究,为皮质类固醇应用于CRS患者的疗效及安全性提供了临床证据。未来可对鼻用皮质类固醇的不同给药方式进行深入探讨,以为临床治疗提供参考。

Chronic rhinosinusitis(CRS)is a chronic inflammatory disease of the nasal mucosa and sinuses,which can seriously affect the quality of life of the patients.For the majority of patients with CRS,intranasal corticosteroids are the primary drug therapy in conjunction with endoscopic sinus surgery in the multimodal integrated treatment of CRS.However,there is still no conclusion on the optimal administration method of nasal corticosteroids and how to achieve the best effect.In recent years,local treatment of CRS with corticosteroid nasal irrigation has been studied at home and abroad,and these studies have provided clinical evidence from the efficacy and safety of corticosteroid application in patients with CRS.In the future,different ways of administration of nasal corticosteroids can be explored in depth to provide reference for the clinical treatment.