慢性肾衰竭维持性血液透析患者焦虑、抑郁状态与生活质量的相关性

Correlation of Anxiety,Depression and Quality of Life in Maintenance Hemodialysis Patients with Chronic Renal Failure

目的分析慢性肾衰竭(CRF)维持性血液透析患者焦虑、抑郁状态与生活质量的相关性。方法选取2019年2月至2020年2月哈尔滨医科大学附属第四医院血液透析科收治的158例行维持性血液透析治疗的CRF患者作为研究组,选取同期152名健康体检者作为对照组。采用焦虑自评量表(SAS)、抑郁自评量表(SDS)、生活质量综合评定问卷(GQOLI-74)评估所有受试者情绪、生活质量情况,分析SAS、SDS评分与GQOLI-74评分的相关性。结果研究组SAS、SDS评分均高于对照组[(58.7±5.5)分比(15.4±2.2)分、(60.3±6.4)分比(14.8±3.3)]分(P<0.01)。研究组GQOLI-74量表躯体功能、社会功能、心理功能、物质生活评分均低于对照组[(54.2±5.3)分比(96.9±1.3)分、(50.2±4.7)分比(95.6±3.4)分、(52.1±5.2)分比(97.6±1.3)分、(51.3±4.9)分比(94.4±1.9)分](P<0.01)。CRF维持性血液透析患者SAS评分与躯体功能、社会功能、心理功能、物质生活评分均呈负相关(r=-0.450,P<0.001;r=-0.424,P<0.001;r=-0.430,P<0.001;r=-0.429,P<0.001),SDS评分与躯体功能、社会功能、心理功能、物质生活评分均呈负相关(r=-0.510,P<0.001;r=-0.530,P<0.001;r=-0.531,P<0.001;r=-0.555,P<0.001)。结论CRF维持性血液透析患者常伴有焦虑、抑郁情况,生活质量较差,且焦虑、抑郁的发生与患者生活质量密切相关。

Objective To analyze the correlation between anxiety,depression and quality of life in maintenance hemodialysis patients with chronic renal failure(CRF).Methods A total of 158 CRF patients undergoing maintenance hemodialysis treatment admitted to the Hemodialysis Department of the Fourth Affiliated Hospital of Harbin Medical University from Feb.2019 to Feb.2020 were included as a study group,and 152 volunteers who came for physical examination during the same period were included as a control group.Self-rating anxiety scale(SAS),self-rating depression scale(SDS)and comprehensive quality of life questionnaire(GQOLI-74)were used to evaluate the mood and quality of life of all the subjects,and the correlation between SAS,SDS and GQOLI-74 scores was analyzed.Results The scores of SAS and SDS in the study group were higher than those in the control group(58.7±5.5 vs 15.4±2.2,60.3±6.4 vs 14.8±3.3)(P<0.01).The scores of physical function,social function,psychological function and material life on the GQOLI-74 scale of the study group were lower than those of the control group(54.2±5.3 vs 96.9±1.3,50.2±4.7 vs 95.6±3.4,52.1±5.2 vs 97.6±1.3,51.3±4.9 vs 94.4±1.9)(P<0.01).In CRF maintenance hemodialysis patients,SAS score was negatively correlated with each dimension score of physical function,social function,psychological function and material life(r=-0.450,P<0.001;r=-0.424,P<0.001;r=-0.430,P<0.001;r=-0.429,P<0.001).The SDS score of CRF maintenance hemodialysis patients was negatively correlated with each dimension score of physical function,social function,psychological function and material life(r=-0.510,P<0.001;r=-0.530,P<0.001;r=-0.531,P<0.001;r=-0.555,P<0.001).Conclusion CRF maintenance hemodialysis patients are often accompanied by anxiety and depression,and their quality of life is poor,and the occurrence of anxiety and depression is closely related to the quality of life of the patients.