生长分化因子-15在心肌梗死后心力衰竭中的研究进展

Research Progress of Growth Differentiation Factor-15 in Heart Failure after Myocardial Infarction

生长分化因子-15(GDF-15)是一种应激反应细胞因子,各种细胞应激信号可促进GDF-15表达。心力衰竭是心肌梗死后最常见的并发症,心肌梗死后心力衰竭发病机制复杂,发病率和病死率较高,严重影响患者生活质量,给社会带来巨大的经济负担,而GDF-15在心肌梗死后心力衰竭发生发展中具有重要作用,尤其在抑制炎症反应、促进血管生成、抗细胞凋亡、降低氧化应激等方面具有心脏保护作用。因此,进一步探究GDF-15在心脏保护方面的临床应用,将为未来心肌梗死后心力衰竭的诊断和治疗提供新选择。

Growth differentiation factor-15(GDF-15)is a stress response cytokine,and various cellular stress signals can promote GDF-15 expression.Heart failure is the most common complication after myocardial infarction.The pathogenesis of heart failure after myocardial infarction is complex,the morbidity and mortality are high,which seriously affect the patients′quality of life and bring a huge economic burden to society.GDF-15 plays an important role in the occurrence and development of heart failure after myocardial infarction,especially in inhibiting inflammation,promoting angiogenesis,anti-apoptosis,reducing oxidative stress and other aspects of cardiac protection.Therefore,further exploring the clinical application of GDF-15 in cardiac protection will provide new options for the diagnosis and treatment of heart failure after myocardial infarction in the future.