肺微血管内皮细胞与支气管肺发育不良的研究进展

Research Progress of Pulmonary Microvascular Endothelial Cells and Bronchopulmonary Dysplasia

支气管肺发育不良(BPD)是一种常见于早产儿的慢性肺部疾病,其主要疾病特点包括肺泡化障碍和肺微血管发育不良等。肺微血管内皮细胞(PMVECs)具有参与构成内皮屏障、促进血管生成、分泌等重要的生理功能,在肺微血管的发育过程中起重要作用。在肺发育进程中,肺微血管可积极促进肺泡生长,并有助于维持新生儿整个产后生命中的肺泡结构。重症BPD患者易伴发肺动脉高压等相关心血管疾病,主要由PMVECs发生内皮-间充质转化所致,这也是早产儿预后不良的重要原因。

Bronchopulmonary dysplasia(BPD)is a chronic lung disease commonly encountered in premature infants.Its main characteristics include alveolar dysplasia and pulmonary microvascular dysplasia.Pulmonary microvascular endothelial cells(PMVECs)have important physiological functions such as participating in the formation of endothelial barriers,promoting angiogenesis and secretion,and play an important role in the development of pulmonary microvessels.During lung development,pulmonary microvessels can actively promote alveolar growth and help maintain the alveolar structure of newborns throughout their postpartum life.Severe BPD patients are prone to associated cardiovascular diseases such as pulmonary hypertension,mainly caused by endothelial-mesenchymal transition of PMVECs,which is also an important reason for poor prognosis in the premature infants.