运动调控缺氧诱导因子表达改善非酒精性脂肪性肝病的研究进展

Research Progress of Exercise Regulation of Hypoxia-inducible Factor Expression to Improve Non-alcoholic Fatty Liver Disease

非酒精性脂肪性肝病(NAFLD)作为常见的慢性肝病在全球发病率逐年增加。缺氧诱导因子(HIFs)是一种氧敏感调节因子,在NAFLD发展中起重要作用。当NAFLD发生时,肝脏积聚的脂质会破坏肝脏局部氧稳态,造成肝脏HIFs水平的改变,HIFs调控下游多条通路,加剧肝脏脂质沉积、炎症反应和纤维化,推动NAFLD发展。运动促进健康的作用与其调控血流、氧供密不可分,而HIFs是运动作用的重要靶点。长期运动可能通过改善肝脏氧供降低HIFs在肝脏发挥的负面作用,从而发挥防治NAFLD的健康效应。然而,目前仍缺乏利用基因干预手段调控HIFs表达,以证实其在运动抗NAFLD中的作用研究。此外,HIFs在肝病中的作用存在分歧,HIFs是否在NAFLD不同病程阶段发挥不同作用仍需进一步研究。

As a common chronic liver disease,non-alcoholic fatty liver disease(NAFLD)sees an incidence increasing year by year in the world.Hypoxia-inducible factors(HIFs)are a kind of oxygen sensitive regulatory factors,which play an important role in the development of NAFLD.When NAFLD occurs,the accumulation of lipids in the liver will destroy the local oxygen homeostasis of the liver,resulting in changes in liver HIFs levels,and HIFs regulate multiple downstream pathways,increasing liver lipid deposition,inflammation and fibrosis,and promoting the development of NAFLD.The role of exercise in promoting health is closely related to the regulation of blood flow and oxygen supply,and HIFs are an important target of exercise.Long-term exercise may reduce the negative effect of HIFs in the liver by improving liver oxygen supply,thereby exerting a health effect in the prevention and treatment of NAFLD.However,there is still a lack of research on the use of gene intervention to regulate the expression of HIFs in order to confirm its role in exercise against NAFLD.In addition,there are controversies in the role of HIFs in liver disease,and whether HIFs play different roles in different stages of NAFLD still needs further study.