幽门螺杆菌感染与胃肠道疾病的相关性及影响因素研究进展

Research Progress in Correlation of Helicobacter Pylori Infection with Gastrointestinal Diseases and Influencing Factors

幽门螺杆菌(Hp)定植于胃上皮细胞表面,主要传播途径为口-口途径、粪-口途径。Hp感染是慢性胃炎、消化性溃疡、胃食管反流病、胃癌、胃黏膜相关性淋巴瘤的主要致病因素,具有明显的流行病学特点,且与性别、年龄、民族、生活卫生习惯、饮食、吸烟、饮酒、职业因素、社会环境因素等因素密切相关。目前,发展中国家的Hp感染率高于发达国家,我国的Hp感染率也处于较高水平,且不同地区的Hp感染率存在差异,并与经济水平、饮食或卫生习惯相关。

Helicobacter pylori(Hp)colonizes the surface of gastric epithelial cells,and its main transmission routes are oral-oral route and fecal-oral route.Hp infection is the main pathogenic factor of chronic gastritis,peptic ulcer,gastroesophageal reflux disease,gastric cancer,and gastric mucosa associated lymphoma.It has obvious epidemiological characteristics and is closely related to multiple factors such as gender,age,nationality,lifestyle,diet,smoking,drinking,occupational factors and social environmental factors.At present,the rate of Hp infection in developing countries is higher than that in developed countries.The rate of Hp infection in China is also at a high level,and there are differences in Hp infection rates in different regions,which are related to economic level,diet or health habits.