端粒长度在肺癌中的临床应用

Clinical Application of Telomere Length in Lung Cancer

肺癌是我国常见的恶性肿瘤,目前肺癌的主要筛查与诊断方式包括影像学检查、血清肿瘤标志物以及组织活检等,但均存在一定局限性,且缺乏预测不良结局的较敏感的指标。端粒长度的异常改变与肺癌发生发展机制密切相关,在肺癌临床研究中逐渐展现出广阔的应用前景。然而,端粒长度在肺癌早期诊断及预后评估方面的研究尚处于探索阶段,相关结论未取得一致性方向。因此,未来研究应考虑更多的循证医学证据,并借助更多大型前瞻性队列以及更敏感特异的检测方式进行深入研究,以为肺癌的诊疗提供新思路。

Lung cancer is a common malignant tumor in China.At present,the main screening and diagnosis methods include imaging examination,serum tumor markers and tissue biopsy,but there are some limitations and lack of sensitive indicators to predict adverse outcomes.The abnormal change of telomere length is closely related to the pathogenesis of lung cancer,and gradually shows a broad application prospect in the clinical research of lung cancer.However,the study of telomere length in the early diagnosis and prognosis assessment of lung cancer is still in the exploratory stage,and the relevant conclusions have not reached a consistent direction.Therefore,future research should consider more evidence-based medical evidence and conduct in-depth research with the help of more large prospective cohort studies and more sensitive and specific detection methods to provide new ideas for the diagnosis and treatment of lung cancer.