长链非编码RNA牛磺酸上调基因1在恶性肿瘤化疗耐药和放射抵抗中的作用及机制研究进展

Research Progress in Role and Mechanism of Long Non-coding RNA Taurine-upregulated Gene 1 in Chemoresistance and Radioresistance of Malignant Tumors

放化疗是恶性肿瘤的一线治疗选择,但化疗耐药和放射抵抗严重影响患者的预后和生活质量。恶性肿瘤化疗耐药和放射抵抗涉及的作用机制复杂,目前尚未完全阐明。长链非编码RNA(lncRNA)牛磺酸上调基因1(TUG1)在恶性肿瘤细胞中表达失调,不仅可通过表观遗传调控基因表达、激活下游信号通路、调节下游蛋白的表达等机制介导恶性肿瘤化疗耐药的发展,还可通过竞争性结合微RNA和直接调节下游蛋白质的表达促进恶性肿瘤细胞对放疗的抵抗性。因此,深入研究lncRNA TUG1在恶性肿瘤化疗耐药和放射抵抗中的作用机制,可以为逆转恶性肿瘤化疗耐药、克服放射抵抗提供新的思路和靶点。

Radiotherapy and chemotherapy is the first-line treatment choice for malignant tumors,and chemoresistance and radioresistance will seriously affect the prognosis and quality of life of the patients.The mechanisms involved in chemoresistance and radioresistance of malignant tumors are complex and have not been fully elucidated.Long non-coding RNA(lncRNA)taurine-upregulated gene 1(TUG1)is misregulated in malignant tumor cells,which can not only mediate the development of chemoresistance by epigenetic regulation of gene expression,activation of downstream signal pathways and regulation of downstream protein expression but also promote radioresistance by competitive binding with miRNA and direct regulation of downstream protein expression.Therefore,an in-depth study of the mechanism of lncRNA TUG1 in chemoresistance and radioresistance of malignant tumors can provide new ideas and targets for reversing the chemoresistance and overcoming radioresistance of malignant tumors.