GLP-1受体激动剂在多囊卵巢综合征病理生理机制中的作用研究进展

Research Progress in Role of GLP-1 Receptor Agonists in Pathophysiology of Polycystic Ovary Syndrome

多囊卵巢综合征(PCOS)是育龄女性常见且具有高度临床异质性的生殖内分泌紊乱性疾病。近年PCOS的发病率呈逐年升高趋势,其代谢生殖障碍的病理生理机制与胰岛素抵抗、高雄激素血症、肠道微生态失衡等相关。胰高血糖素样肽-1(GLP-1)可改善PCOS患者体质量、胰岛素抵抗、高雄激素血症以及生殖功能紊乱,因此,GLP-1受体激动剂在PCOS的发生发展和临床应用中受到广泛关注。深入研究GLP-1受体激动剂在PCOS病理生理机制中的具体作用,可以为PCOS患者的治疗提供新思路。

Polycystic ovary syndrome(PCOS)is a common and highly heterogeneous disease of reproductive endocrine disorder in women of childbearing age.In recent years,the incidence of PCOS has been increasing significantly.The pathophysiological mechanism of its metabolic reproductive disorder is related to insulin resistance,hyperandrogenemia and intestinal microecological imbalance.Since glucagon-like peptide-1(GLP-1)can improve body weight,insulin resistance,hyperandrogenemia and reproductive dysfunction in PCOS patients,its receptor agonists have gained wide attention in the development and clinical application of PCOS.An in-depth study of the specific role of GLP-1 receptor agonists in the pathophysiological mechanism of PCOS can provide new ideas for the treatment of PCOS patients.