多感官刺激疗法对老年阿尔茨海默病患者激越行为和认知功能的影响

Effects of Multi-sensory Stimulation Therapy on Agonistic Behavior and Cognitive Function in Elderly Patients with Alzheimer′s Disease

目的探讨多感官刺激疗法(MSS)对老年阿尔茨海默病(AD)患者激越行为和认知功能的影响。方法选取2019年5月至2021年5月联勤保障部队第九八〇医院收治的64例老年AD患者作为研究对象,采用随机数字表法分为对照组和研究组,各32例。其中,对照组给予常规康复训练(包括日常生活能力、记忆力、智力及语言能力等),研究组在对照组的基础上给予MSS,比较两组治疗前后AD行为病理学评定量表(BEHAVE-AD)评分、Cohen-Mansfield激越行为量表(CMAI)评分、简易智力状态检查量表(MMSE)评分、蒙特利尔认知评估量表(MoCA)评分及不良反应发生情况。结果BEHAVE-AD评分组间、时点间的主效应差异有统计学意义(P<0.01),组间与时点间存在交互作用(P<0.01);与治疗前相比,治疗后两组的BEHAVE-AD评分均降低,且研究组低于对照组(P<0.01)。躯体攻击行为、躯体非攻击行为、语言激越行为评分组间、时点间的主效应差异有统计学意义(P<0.01),组间与时点间存在交互作用(P<0.01);与治疗前相比,治疗后两组的躯体攻击行为、躯体非攻击行为、语言激越行为评分均降低,且研究组低于对照组(P<0.01)。MMSE评分和MoCA评分组间、时点间的主效应差异有统计学意义(P<0.01),组间和时间点存在交互作用(P<0.01);与治疗前相比,治疗后两组的MMSE评分及MoCA评分均升高,且研究组高于对照组(P<0.01)。两组治疗期间均无明显不良反应发生。结论与常规康复训练相比,MSS可明显改善老年AD患者的激越行为和认知功能。

Objective To explore the effects of multi-sensory stimulation(MSS)on agonistic behavior and cognitive function in elderly patients with Alzheimer′s disease(AD).Methods Sixty-four elderly patients with AD admitted to the 980th Hospital of the Chinese PLA Joint Logistics Support Force from May 2019 to May 2021 were included,and were divided into a control group and a study group,32 cases each,using the random number table method.The control group was given conventional rehabilitation training(including daily living ability,memory,intelligence and language ability,etc.),while the study group was given MSS on the basis of the control group′s regimen,and the behavioral pathology in AD rating scale(BEHAVE-AD)scores,Cohen-Mansfield agitation inventory(CMAI)scores,mini-mental state examination(MMSE)scores,Montreal cognitive assessment(MoCA)scores before and after treatment and the occurrence of adverse effects were compared between the two groups.Results The main effects of BEHAVE-AD scores differed statistically between groups and time points(P<0.01),and there was an interaction between groups and time points(P<0.01);BEHAVE-AD scores were lower in both groups after treatment compared with before treatment,and were lower in the study group than in the control group(P<0.01).There were statistically significant differences in the main effects of somatic aggression,somatic nonaggressive behavior,and verbal agitation scores between groups and time points(P<0.01),and there were interactions between groups and time points(P<0.01).Compared with before treatment,the somatic aggression,somatic nonaggressive behavior,and verbal agitation scores were lower in both groups after treatment,and were lower in the study group than the control group(P<0.01).There were statistically significant differences in the main effects of MMSE scores and MoCA scores between groups and time points(P<0.01),and there were interactions between groups and time points(P<0.01);MMSE scores and MoCA scores were higher in both groups after treatment compared with those before treatment,and were higher in the study group compared with the control group(P<0.01).No significant adverse effects occurred during treatment in either group.Conclusion Compared with conventional rehabilitation training,MSS can significantly improve agonistic behavior and cognitive function in elderly patients with AD.