液体活检在结直肠癌筛查中的进展及意义

Progress and Significance of Liquid Biopsy in Colorectal Cancer Screening

结直肠癌(CRC)确诊时大部分已经是晚期,早期发现可降低死亡率、改善预后。液体活检取材方便、易于动态监测,其中通过多因子联合检测可提高CRC的筛查效果。近年发现,液体活检在CRC早期筛查、诊断、肿瘤进展、转移、预后及指导用药等方面均有预测价值,并可通过动态监测实时反映肿瘤在体内的变化及转归。未来,仍需继续探索寻找CRC液体活检中新的预测因子,并通过新的检测技术及相关检测技术的联合应用提高不同指标的灵敏度和特异度,为规模性的CRC早期筛查奠定理论基础。

Most colorectal cancer(CRC)are diagnosed at an advanced stage,while early detection can reduce the mortality and improve the prognosis.Liquid biopsy is convenient to obtain samples and easy for dynamic monitoringd,among which the combined detection of multiple factors can improve the screening effect of CRC.In recent years,it has been discovered that liquid biopsy has predictive value in the early screening,diagnosis,tumor progression,metastasis,prognosis,and medication guidance for CRC;it can also reflect the changes and outcomes of tumors in vivo through dynamic monitoring.In the future,it is still necessary to continue to explore and find new predictors in CRC liquid biopsy,and to improve the sensitivity and specificity of different indicators through the combined application of new detection technologies and related detection technologies,so as to provide a theoretical basis for the large-scale early screening of CRC.