正念减压疗法联合二甲双胍对多囊卵巢综合征患者精神状态和生活质量的影响

Effects of Mindfulness-based Stress Reduction Therapy Combined with Metformin on Mental State and Quality of Life of Patients with Polycystic Ovary Syndrome

目的探讨正念减压疗法联合二甲双胍对多囊卵巢综合征患者精神状态和生活质量的影响。方法选取2018年6月至2020年8月邯郸市中心医院收治的96例多囊卵巢综合征患者为研究对象,根据治疗方法不同分为对照组和试验组,各48例。对照组在月经或撤退性出血第3天开始口服二甲双胍,每次0.5 g,每日3次;试验组在对照组的基础上实施正念减压疗法。两组均治疗6周。比较两组治疗前后体质指数(BMI)、空腹血糖、抑郁自评量表(SDS)评分、焦虑自评量表(SAS)评分、性激素(促黄体生成素、睾酮、卵泡刺激素)、生活质量评分变化,以及不良反应发生情况。结果治疗后,试验组患者的BMI、空腹血糖低于对照组[(22.17±1.27)kg/m^(2)比(23.06±1.62)kg/m^(2)、(6.53±0.34)mmol/L比(8.21±0.41)mmol/L](P<0.01)。治疗后,试验组患者的SDS、SAS评分低于对照组[(36.29±3.72)分比(40.12±4.38)分、(38.55±3.93)分比(45.09±4.87)分](P<0.01)。治疗后,试验组患者促黄体生成素、睾酮及卵泡刺激素低于对照组[(6.04±1.21)U/L比(8.25±1.72)U/L、(1.54±0.19)nmol/L比(2.02±0.29)nmol/L、(3.16±0.87)U/L比(4.24±1.12)U/L](P<0.01),生活质量评分高于对照组[(67.5±6.0)分比(56.8±4.7)分](P<0.01)。两组总不良反应发生率比较差异无统计学意义(P>0.05)。结论正念减压疗法联合二甲双胍能够缓解多囊卵巢综合征患者的负面情绪,调节性激素水平,且可以提高患者生活质量,安全性较好。

Objective To investigate the effect of mindfulness-based stress reduction therapy combined with metformin on mental state and quality of life of patients with polycystic ovary syndrome(PCOS).Methods A total of 96 patients with PCOS admitted to Handan Central Hospital from Jun.2018 to Aug.2020 were included.According to the treatment methods,they were divided into a control group and a test group,with 48 cases in each.The control group was given metformin(on the 3rd day of menstruation or withdrawal bleeding,oral metformin,0.5 g each time,3 times a day),and the test group was given mindfulness-based stress reduction therapy combined with metformin.Both groups were treated for 6 weeks.The body mass index(BMI),fasting blood glucose,self-rating depression scale(SDS)score,self-rating anxiety scale(SAS)score,sex hormones(luteinizing hormone,testosterone,follicle-stimulating hormone),and changes in quality of life scores before and after treatment,as well as the occurrence of adverse reactions of the two groups were compared.Results After treatment,the BMI and fasting blood glucose of the test group were lower than those of the control group[(22.17±1.27)kg/m^(2)vs(23.06±1.62)kg/m^(2),(6.53±0.34)mmol/L vs(8.21±0.41)mmol/L](P<0.01).After treatment,the SDS score and SAS score of the test group were lower than those of the control group[(36.29±3.72)point vs(40.12±4.38)point,(38.55±3.93)point vs(45.09±4.87)point](P<0.01).After treatment,the sex hormones such as luteinizing hormone,testosterone and follicle-stimulating hormone in the test group were lower than those in the control group[(6.04±1.21)U/L vs(8.25±1.72)U/L,(1.54±0.19)nmol/L vs(2.02±0.29)nmol/L,(3.16±0.87)U/L vs(4.24±1.12)U/L](P<0.01),and the quality of life score of the test group was higher than that of the control group[(67.5±6.0)point vs(56.8±4.7)point](P<0.01).There was no significant difference in the incidence of total adverse reactions between the two groups(P>0.05).Conclusion Mindfulness-based stress reduction therapy combined with metformin can relieve the negative emotions of the patients with PCOS,regulate the level of sex hormones,and improve the quality of life,with good safety.