IRGM在自身免疫性疾病中的研究进展

Research Progress of IRGM in Autoimmune Diseases

自身免疫性疾病是一种累及多脏器、多器官的全身系统性疾病。自噬在维持免疫系统稳定和功能方面发挥重要作用,自噬功能失常与免疫性疾病的发生有关。免疫相关GTP酶家族M(IRGM)基因作为一种自噬相关基因,在组装自噬体中发挥主要作用,同时通过多种途径调节自噬。目前大规模的全基因组关联研究将IRGM与克罗恩病和其他自身免疫性疾病遗传联系起来。但IRGM在自身免疫性疾病中的发生发展尚未完全明确,了解这些机制将为自身免疫性疾病的治疗提供新目标。

Autoimmune disease is a systemic disease involving multiple organs.Autophagy plays an important role in maintaining the stability and function of the immune system.The dysfunction of autophagy is often related to the occurrence of immune diseases.As an autophagy related gene,immunity-related GTPase family M(IRGM)gene plays a major role in the assembly of autophagosomes and regulates autophagy through a variety of ways.At present,large-scale genome-wide association studies have linked IRGM with Crohn′s disease and other autoimmune diseases.However,the occurrence and development of IRGM in autoimmune diseases has not been completely clear.Understanding these mechanisms will provide new targets for therapeutic intervention of autoimmune diseases.