凝血指标与非小细胞肺癌关系的研究进展

Research Progress in Relationship between Coagulation Indexes and Non-small Cell Lung Cancer

非小细胞肺癌(NSCLC)患者多存在凝血-纤溶系统紊乱,普遍表现为凝血指标异常。凝血功能异常会促进肿瘤细胞的侵袭、迁移,因而通过观察凝血指标可在一定程度上体现NSCLC的进展情况。在高凝状态下,血小板增多、纤维蛋白原增高可形成微血栓,导致肿瘤细胞逃避免疫攻击而影响治疗效果。另外,凝血指标与NSCLC患者并发血栓性疾病的风险也相关,凝血指标可能与患者的预后也存在一定联系。因此,明确凝血指标与NSCLC的关系,可为未来NSCLC的治疗提供参考。

Most patients with non-small cell lung cancer(NSCLC)have coagulation-fibrinolysis system disorders,which are generally manifested as abnormal coagulation indexes.Abnormal coagulation function will promote the invasion and metastasis of tumor cells,so the progress of NSCLC can be reflected to a certain extent by observing coagulation indexes.In hypercoagulable state,thrombocytosis and fibrinogen increase can form microthrombosis,causing tumor cells to escape immune attack and affecting the therapeutic effect.In addition,coagulation indicators are also related to the risk of thrombotic disease in NSCLC patients,and coagulation indicators may also be related to the prognosis of the patients.Therefore,clarifying the relationship between coagulation indexes and NSCLC can provide references for the treatment of NSCLC in the future.