纳米颗粒在抗甲氧西林耐药金黄色葡萄球菌感染中的研究进展

Research Progress of Nanoparticles in Anti-Methicillin-resistant Staphylococcus Aureus Infection

耐甲氧西林金黄色葡萄球菌(MRSA)是引起医院和社区感染的重要病原菌,传播速度快、患者病死率高,给社会带来沉重负担。MRSA对多种抗菌药物均会产生耐药性,因此治疗MRSA感染具有较大的挑战性,而纳米技术的快速发展为这一难题的解决提供了可能。其中,功能性纳米材料既可作为抗菌药物,又可作为抗菌载体用于抗菌治疗。功能性纳米材料可以绕过MRSA的耐药性防御机制,在抗MRSA感染中显示出巨大潜力,未来有望应用于临床,解决因细菌耐药而产生的治疗难题。

Methicillin-resistant Staphylococcus aureus(MRSA)is an important pathogen causing hospital and community-acquired infections with rapid transmission and high mortality,posing a heavy burden to the whole society.The treatment of MRSA infection is challenging since it has developed the resistance to various antibiotic reagents.The rapid development of nanotechnology provides a good solution to this challenge.Functional nanomaterials can be used as both antimicrobial drugs and antimicrobial carriers for antimicrobial therapy.Functional nanomaterials can bypass the resistance defense mechanism of MRSA and show great potential in anti-MRSA infection.In the future,they are expected to be used in the clinical practice to solve the treatment problem due to bacterial drug resistance.