胆管癌分子靶点成纤维细胞生长因子受体的研究进展

Research Progress of Molecular Target Fibroblast Growth Factor Receptor in Cholangiocarcinoma

胆管癌起源于胆管上皮,是一种难治性的胆道恶性肿瘤,手术切除是其最有效的治疗方法。但由于临床症状出现较晚,大部分患者就诊时已处于晚期,往往失去手术机会,预后较差。近年来对胆管癌分子靶点的研究取得了重大进展,已经明确成纤维细胞生长因子受体(FGFR)家族在胆管癌中具有较高的突变频率,其异常激活和扩增与胆管癌的发生发展密切相关。目前已经有FGFR抑制剂用于胆管癌的治疗,取得了不错的效果,给晚期或转移性胆管癌患者带来了新的希望。

Cholangiocarcinoma(CCA)originates from the biliary epithelium,which is a kind of refractory malignant biliary tumor,and surgical resection is the most effective treatment.However,due to the late appearance of clinical symptoms,most patients are already in the advanced stage when they seek treatment,and have lost the chance of surgery,which causes poor prognosis.In recent years,remarkable progress has been made in the study of the molecular targets of CCA.It has been clarified that the fibroblast growth factor receptor(FGFR)family has a high mutation frequency in CCA,and its abnormal activation and amplification are closely related to the occurrence and development of CCA.FGFR inhibitors have been used in the treatment of CCA and achieved good results,bringing new hope for patients with advanced or metastatic CCA.