单核细胞/淋巴细胞比值与糖尿病足患者下肢动脉病变的相关性研究

Relationship between monocyte-to-lymphocyte ratio and lower extremityarterial disease in patients with diabetic foot disease

目的:探讨单核细胞/淋巴细胞比值(monocytes to lymphocytes ratio,MLR)与糖尿病足患者下肢动脉病变(lower extremity arterial disease,LEAD)的相关性。方法:选取2020年4月至2023年4月于陆军军医大学第一附属医院住院治疗的2型糖尿病足患者243例,分为下肢动脉病变组(LEAD,n=103)和非下肢动脉病变组(non-lower extremity arterial disease,NLEAD,n=140),分析MLR与LEAD的相关性。结果:LEAD组MLR显著高于NLEAD组[0.46(0.29,0.63) vs. 0.38(0.26,0.58)(P<0.05)]。logistic回归分析结果显示,MLR、年龄、胆固醇、血肌酐是糖尿病足患者发生下肢血管病变的影响因素(P<0.05)。受试者工作特征曲线分析表明,MLR预测糖尿病足患者下肢血管病变的最佳切点为0.34,敏感度和特异度分别为69.9%和46.4%。结论:MLR与2型糖尿病足患者LEAD的发生相关。

Objective:To evaluate the relationship between the monocyte-to-lymphocyte ratio(MLR)and lower extremity arterial disease(LEAD)in patients with diabetic foot disease.Methods:We included a total of 243 patients with type 2 diabetic foot problems hospitalized in The First Affiliated Hospital of Army Medical University from April 2020 to April 2023.They were divided into LEAD group(n=103)and non-LEAD group(n=140)to analyze the relationship between MLR and LEAD.Results:The MLR in the LEAD group was significantly higher than that in the non-LEAD group(0.46[0.29,0.63]vs.0.38[0.26,0.58],P<0.05).The logistic regres⁃sion analysis showed that MLR,age,serum cholesterol,and serum creatinine were risk factors for LEAD in patients with diabetic foot disease(P<0.05).The receiver operating characteristic curve analysis showed that the optimal cut-off point for MLR predicting lower extremity arterial disease in patients with diabetic foot problems was 0.34,with sensitivity and specificity being 69.9%and 46.4%,respectively.Conclusion:MLR is associated with the development of LEAD in patients with type 2 diabetic foot disease.