摘要
目的:探讨扶正祛邪养阴方辅助化疗治疗晚期气阴两虚型非小细胞肺癌(NSCLC)患者的疗效。方法:选取2020年1月至2021年9月德驭医疗马鞍山总医院收治的晚期NSCLC患者120例作为研究对象,按照随机数字表法随机分为对照组和观察组,每组60例,对照组给予多西他赛+顺铂化疗,观察组在对照组基础上加用扶正祛邪养阴方治疗。比较2组患者间近期疗效,中医症状积分,肿瘤标志物血清糖类抗原125(CA125)、细胞角质素片段抗原21-1(CYFRA21-1)和癌胚抗原(CEA),免疫功能自然杀伤细胞(NK)、细胞毒T细胞(Tc)、和调节性T细胞(Treg)比例,生命质量(卡诺夫斯凯计分评分),不良反应及1年无进展生存期、无进展生存率及1年总生存率。结果:2组患者间疾病控制率、1年无进展生存期、无进展生存率及1年总生存率比较差异无统计学意义(P>0.05);治疗后,观察组中医症状积分、肿瘤标志物(CA125、CYFRA21-1和CEA)、免疫功能(NK、Tc、和Treg比例)、卡诺夫斯凯计分评分和对照组差异均有统计学意义(均P<0.05),不良反应(胃肠道反应、骨髓抑制和肝功能异常)发生率显著低于对照组(P<0.05)。结论:扶正祛邪养阴方辅助化疗治疗晚期气阴两虚型NSCLC患者,能有效缓解临床症状,降低肿瘤标志物水平,提高免疫功能,降低不良反应发生率。
Objective:To observe the effect of Fuzheng Quxie Yangyin Decoction supplemented with chemotherapy in the treatment of advanced non-small cell lung cancer(NSCLC)of qi-yin deficiency.Methods:A total of 120 patients with advanced NSCLC who were treated in the Maanshan General Hospital of Ranger-Duree Healthcare between January 2020 and September 2021 were selected and divided into control group(60 cases,docetaxel+cisplatin chemotherapy)and observation group(60 cases,Fuzheng Quxie Yangyin Decoction on the basis of control group)according to the random number table.The short-term efficacy,traditional Chinese medicine(TCM)symptom scores,tumor markers[serum carbohydrate antigen 125(CA125),cytokeratin fragment antigen 21-1(CYFRA21-1),carcinoembryonic antigen(CEA)],immune function[proportions of natural killer cell(NK),cytotoxic T cell(Tc)and regulatory T cell(TreGs)],quality of life[Karnofsky Performance Status Scale(KPS)score],adverse reactions,1-year progression-free survival time,progression-free survival rate and 1-year overall survival rate were compared between the two groups.Results:There were no differences in the disease control rate,1-year progression-free survival time,progression-free survival rate and 1-year overall survival rate between the two groups(P>0.05).After treatment,differences were found in the TCM symptom scores,tumor markers(CA125,CYFRA21-1,CEA),immune function(proportions of NK,Tc and Treg)and KPS score between observation group and control group(P<0.05).The incidence of adverse reactions(gastrointestinal reactions,bone marrow suppression,abnormal liver function)in observation were lower than those in control group(P<0.05).Conclusion:Fuzheng Quxie Yangyin Decoction combined with chemotherapy can relieve the clinical symptoms,reduce tumor markers,improve the immune function,and lower adverse reactions in the treatment of patients with advanced NSCLC of qi-yin deficiency.
作者
江南
牧辰
江孝华
秦碧勇
JIANG Nan;MU Chen;JIANG Xiaohua;QIN Biyong(Department of Oncology,Maanshan General Hospital of of Ranger-duree Healthcare,Maanshan 243000,China;Department of Neurology,Shiyan Renmin Hospital,Shiyan 442000,China)
出处
《世界中医药》
CAS
2023年第18期2651-2655,2660,共6页
World Chinese Medicine
基金
湖北省卫生健康委员会2019~2020年度指导性项目(WJ2019F049)。
关键词
扶正祛邪养阴方
多西他赛
顺铂
免疫功能
无进展生存期
非小细胞肺癌
肿瘤标志物
疗效
Fuzheng Quxie Yangyin Decoction
Docetaxel
Cisplatin
Immune function
Progression-free survival time
Non-small cell lung cancer
Tumor markers
Efficacy