血清糖类抗原125和25-羟维生素D对宫颈癌患者预后的评估价值

Prognostic value of serum carbohydrate antigen 125 and 25-hydroxyvitamin D in the patients with cervical cancer

目的探讨糖类抗原125(CA125)和25-羟维生素D[25-hydroxy vitamin D,25(OH)D]对宫颈癌患者预后的评估价值。方法选取2020年1月至2021年1月漯河市第三人民医院收治的95例宫颈癌患者。根据血清CA125和25(OH)D水平中位数,分别将患者分为高CA125组和低CA125组、高25(OH)D组和低25(OH)D组,探讨血清CA125和25(OH)D对宫颈癌预后的评估价值。结果多因素COX回归分析显示,血清CA125[HR(95%CI):1.913~12.326),P<0.001]和25(OH)D[HR(95%CI):0.211(0.095~0.472),P<0.001]均是宫颈癌患者预后的独立影响因素。血清CA125预测宫颈癌患者预后的曲线下面积(AUC)为0.786(95%CI:0.686~0.886,P<0.001),血清25(OH)D为0.747(95%CI:0.633~0.862,P<0.001),血清CA125联合血清25(OH)D为0.861(95%CI:0.780~0.941,P<0.001)。高CA125组(中位总生存期7.67个月)和低25(OH)D组(中位总生存期11.00个月)的总生存期低于低CA125组(中位总生存期6.80个月)和高25(OH)D组(中位总生存期11.23个月),差异均有统计学意义(P均<0.001)。结论血清CA125和25(OH)D是宫颈癌患者预后的有效预测指标,且两者联合的预测价值更高。

Objective To investigate the prognostic value of cancer antigen 125(CA125)and 25-hydroxyvitamin D(25(OH)D)in the patients with cervical cancer.Methods The 95 patients with cervical cancer were selected from Luohe Third People’s Hospital from January 2020 to January 2021.According to the median values of serum CA125 and 25(OH)D,all the patients were divided into the high CA125 and the low CA125 groups,as well as the high 25(OH)D and the low 25(OH)D groups.The predictive value of serum CA125 and 25(OH)D on cervical cancer were observed.Results The multivariate COX results showed that serum CA125[HR(95%CI):4.855(1.913-12.326),P<0.001]and serum 25(OH)D[HR(95%CI):0.211(0.095-0.472),P<0.001]were the independent prognostic factors for patients with cervical cancer.Serum CA125 had an area under the curve(AUC)of 0.786(95%CI:0.686-0.886,P<0.001)for predicting the prognosis,serum 25(OH)D had an AUC of 0.747(95%CI:0.633-0.862,P<0.001),serum CA125 combined with serum 25(OH)D had a better predictive value with AUC of 0.861(95%CI:0.780-0.941,P<0.001).The overall survival levels in the high CA125 group(median overall survival:7.67 months)and the low 25(OH)D group(median overall survival:11.00 months)were significantly lower than those in the low CA125 group(median overall survival:6.80 months)and the high 25(OH)D group(median overall survival:11.23 months),with statistically significant differences(P<0.001).Conclusion Serum CA125 and 25(OH)D are effective prognostic indicators for patients with cervical cancer,and their combination has higher predictive value for the prognosis.