转录因子Kruppel样因子11在肿瘤中的表达及功能研究进展

Research progress in expression and functions of transcription factor Kruppel-like factor 11 in human cancers

Kruppel样因子11(Kruppel-like factor 11,KLF11)是Kruppel样锌指转录因子家族的成员,主要发挥转录调节作用。KLF11在多种常见肿瘤组织中异常表达,并参与肿瘤的发生发展,包括乳腺癌、肺癌、胰腺癌、子宫内膜癌等。研究发现,KLF11参与TGF-β-Smads信号通路、上皮间质转化(epithelial-mesenchymal transition,EMT)的发生以及与微小RNA(microRNAs)相互作用,并且可能负性调节干性肿瘤细胞功能,说明KLF11可能在肿瘤的诊断、治疗和预后预测中存在重要的应用价值。本文就KLF11在肿瘤中表达及功能的研究进展作简要综述。

Kruppel-like factor 11(KLF11)is a member of the Kruppel-like zinc finger transcription factor family and mainly plays a role in transcriptional regulation.Current evidence has shown that KLF11 is deregulated in cancer tissues,such as breast,lung,pancreatic and endometrial cancers.This abnormal expression is involved in tumorigenesis.Studies have found that KLF11 is involved in the TGF-β-Smads signaling pathway and process of epithelial-mesenchymal transition(EMT).Besides,KLF11 participates in the interaction with microRNAs,and may as a negative regulator in cancer stem cells,suggesting its potential value in tumor diagnosis,treatment and prognosis prediction.This article reviews the research progress of KLF11 expression and function in human cancers.