Presepsin在儿童脓毒症中的研究进展

Research Progress of Presepsin in Children with Sepsis Reviewer

脓毒症是一种危及生命的疾病,是造成儿科患者发病、乃至死亡的主要原因之一,早期诊断并及时治疗可提高患儿生存率。血培养、C-反应蛋白(CRP)、降钙素原(PCT)、白细胞介素-6(IL-6)等在脓毒症诊断中的应用是目前研究的热点,但其特异度和灵敏度都有局限性,且检测时间过长。可溶性白细胞分化抗原14亚型(sCD14-ST)又称Presepsin,是一种新型生物标志物,它不仅对儿童脓毒症的早期诊断有较高的特异度和灵敏度,对判定脓毒症病情严重程度、抗菌药物治疗效果和预后也有一定的评估价值,且检测方法快捷、准确,具有临床应用的可行性。文章就Presepsin对脓毒症诊断价值评价的研究进行综述,以期开展更多的临床研究指导其应用。

Sepsis,a life-threatening disease,is one of the main causes of morbidity and even death in pediatric patients.Early diagnosis and timely treatment can improve the patient survival rate.The application of blood culture,C-reactive protein(CRP),procalcitonin(PCT),interleukin-6(IL-6)in the diagnosis of sepsis is a hot spot of current research,but its specificity and sensitivity are limited,and the detection time is too long.Soluble leukocyte differentiation antigen 14 subtype(sCD14-ST,or Presepsin)is a novel biomarker that not only has high specificity and sensitivity in the early diagnosis of sepsis in children,but also has certain value in evaluating the severity of sepsis,antimicrobial treatment and prognosis,and the detection method is fast and accurate.It has the feasibility of clinical application.This article reviews the evaluation of Presepsin in the diagnosis of sepsis,with a view to conducting more clinical studies to guide its application.