低频重复经颅磁刺激改善慢性失眠的疗效观察

Observation on the therapeutic effect of low-frequency repetitive transcranial magnetic stimulation in improving chronic insomnia

目的观察低频重复经颅磁刺激(rTMS)改善慢性失眠的疗效,并观察疗效维持时间。方法选取2021年2月至2022年9月广州医科大学附属第六医院收治的慢性失眠患者100例,依据随机数表法分为对照组(假刺激组,n=51)和治疗组(低频磁刺激组,n=49)。两组均接受连续2周的经颅磁刺激,分别在治疗前和治疗2、4、6、8周比较两组患者的抑郁症筛查量表(PHQ-9)、匹兹堡睡眠质量指数(PSQI)评分,并对整个过程中的不良反应情况进行对比分析。结果治疗2、4、6周后,治疗组的PHQ-9、PSQI评分均低于对照组,差异具有统计学意义(P<0.05);治疗前、治疗8周后,两组的PSQI、PHQ-9评分比较,差异无统计学意义(P>0.05)。治疗组患者的总有效率为95.92%,明显高于对照组的80.39%,差异有统计学意义(P<0.05)。所有患者在整个治疗过程中均无严重不良反应。结论rTMS能有效改善慢性失眠患者睡眠质量,并且是安全、有效的治疗方法。

Objective To observe the therapeutic effect of low-frequency repetitive transcranial magnetic stimulation(rTMS)in improving chronic insomnia and observe the duration of the therapeutic effect.Methods A total of 100 patients with chronic insomnia admitted to the Sixth Affiliated Hospital of Guangzhou Medical University from February 2021 to September 2022 were selected and divided into a control group(the pseudostimulation treatment group,n=51)and a treatment group(the rTMS treatment group,n=49)using the random number table method.Both groups received continuous transcranial magnetic stimulation for 2 weeks.The patient health questionnaire-9(PHQ-9)and Pittsburgh sleep quality index(PSQI)scores of the two groups before treatment,two weeks after treatment,four weeks after treatment,six weeks after treatment,and eight weeks after treatment,were observed,and the adverse reactions throughout the entire process were compared and analyzed.Results The PHQ-9 and PSQI scores at 2,4,and 6 weeks of treatment of the treatment group were lower than those of the control group,with statistically significant differences(P<0.05).The PSQI and PHQ-9 scores at 8 weeks of treatment of the treatment group were lower than those of the control group,with no statistically significant difference(P>0.05).The total effective rate of patients in the observation group was 95.92%,significantly higher than 80.39% of the control group,with statistically significant difference(P<0.05).All patients had no serious adverse reactions throughout the entire treatment process.Conclusion rTMS treatment can effectively improve the sleep quality of patients with chronic insomnia and is a safe as well as effective therapy.