培哚普利联合氢氯噻嗪治疗原发性高血压并慢性心力衰竭疗效及对患者心功能和炎症因子的影响

Clinical effect of Perindopril combined with hydrochlorothiazide in cardiac function and inflammatory factors and treatment of essential hypertension complicated with chronic heart failure

目的 分析培哚普利联合氢氯噻嗪治疗原发性高血压合并慢性心力衰竭的临床效果及对患者心功能、炎性因子水平的影响。方法 将河南省人民医院2020年至2021年期间收治的88例高血压合并慢性心力衰竭患者纳入本次研究,随机将所有患者分为观察组以及对照组,每组44例。对照组患者给予单独的培哚普利进行治疗,观察组患者则通过培哚普利与氢氯噻嗪进行联合治疗,主要对比两组患者的临床疗效、心功能以及炎性因子白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)水平。结果 (1)两组患者治疗后的炎性因子指标均比治疗前有所降低,且观察组患者较之于对照组降低更明显(P<0.05);(2)两组患者治疗后的左心室舒张末期内径(LVEDD)、右心室舒张末期内径(LVESD)以及左心室射血分数(LVEF)水平均有所改善,且观察组患者较之于对照组显著更优(P<0.05);(3)观察组治疗后的舒张压和收缩压均比对照组下降显著(P<0.05);(4)观察组患者的临床治疗总有效率较之于对照组显著增高(P<0.05);(5)观察组患者治疗后生活质量较之于对照组显著改善(P<0.05)。结论 将培哚普利与氢氯噻嗪两种药物联合应用于原发性高血压合并慢性心力衰竭的治疗效果显著,不仅能够使得血管壁的炎症反应得到有效抑制,还能够促进患者心功能显著改善,值得推广。

Objective To analyze the clinical effects of perindopril combined with hydrochlorothiazide in the treatment of essential hypertension complicated with chronic heart failure and the effects on the level of cardiac function and inflam-matory factors in patients.Methods Totally 88 patients with hypertension complicated with chronic heart failure admit-ted to Henan Provincial People's Hospital from 2020 to 2021 were included in this study.All patients were randomly di-vided into observation group and control group,with 44 cases in each group.The control group was treated with perindo-pril only,while the observation group was treated with perindopril combined with hydrochlorothiazide.The clinical effi-cacy,cardiac function and inflammatory factor(IL-6,TNF-α,CRP)levels of the two groups were mainly compared.Results@The inflammatory factor indexes of two groups were decreased after treatment compared with before treat-ment,and the decrease of observation group was more obvious than that of control group(P<0.05);②The levels of LVEDD,LVESD and LVEF in two groups were improved after treatment,and the observation group was significantly better than that of the control group(P<0.05);③After treatment,the diastolic blood pressure and systolic blood pressure in the observation group were significantly decreased compared with the control group(P<0.05).@The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).The quality of life after treatment in observation group was significantly better than that of control group(P<0.05).Conclusion The combined application of peridopril and hydrochlorothiazide in the treatment of essential hypertension with chronic heart failure has significant effects,which can not only effectively inhibit the inflammatory response of blood vessel wall,but also significantly improve the cardiac function of patients,and is worthy of promotion.