摘要
The tRNA-derived fragments(tRFs)are small non-coding RNAs containing fewer than 50 nucleotides that are abundant in humans and have various biological functions.However,their roles and mechanisms in melanogenesis are unclear.In this study,we firstly investigated the change in the expres-sion profile of tRFs in melanocytes after UVB irradiation through tsRNA sequencing.UVB-induced melanogenesis led to the upregulation of 119 tRFs and the downregulation of 103 tRFs.
基金
supported by the National Natural Science Foundation of China(No.82103704)
the Natural Science Foundation of Hunan Province(China)(No.2021JJ20089,2022JJ70148)
Wisdom Accumulation and Talent Cultivation Project of the Third Xiangya Hospital of Central South Uni-versity,Hunan,China(No.YX202007)
the Hunan Science and Technology Innovation Project(China)(No.2021RC3035).
