miR-146a介导TLR4/NF-κB信号通路延缓骨关节炎的作用及机制

The effect and mechanism of miR-146a mediating TLR4/NF-κB signaling pathway in osteoarthritis

骨关节炎(osteoarthritis,OA)作为慢性低度炎症性疾病,对它的研究一直是重点和难点,因此如何延缓OA的进展成为最主要的问题。miR-146a作为维持软骨稳态的关键调节因子,其表达的变化对软骨退变和炎症具有调节作用。Toll样受体4(toll-like receptor 4,TLR4)/核因子-κB(nuclear Factor-κB,NF-κB)信号通路通过调节免疫炎症反应,维持软骨代谢稳态。虽然miR-146a介导TLR4/NF-κB信号通路延缓OA已有研究,但是具体作用机制仍然不完善。本研究通过miR-146a介导TLR4/NF-κB信号通路对炎症及软骨细退变方面的综述,为OA的治疗提供理论依据和潜在分子靶标。

Osteoarthritis(OA)is a chronic low-grade inflammatory disease.It has always been the focus and difficulty.How to delay the progress of OA has become the most important problem.As a key regulator to maintain cartilage homeostasis,miR-146a has a regulatory effect on cartilage degeneration and inflammation.Toll-like receptor 4(TLR4)/Nuclear Factor-κB(NF-κB)signaling pathway maintains the metabolic homeostasis of cartilage by regulating immune and inflammatory responses.Although it has been studied that miR-146a mediates TLR4/NF-κB signaling pathway to delay OA,the specific mechanism is still not perfectly understood.This study reviews the effects of miR-146a on inflammatory factors,chondrocyte apoptosis,and cartilage extracellular matrix degradation through TLR4/NF-κB signaling pathway,so as to provide theoretical basis and potential molecular targets for the treatment of OA.