沙库巴曲缬沙坦联合尼可地尔对冠心病患者大动脉僵硬度及心室重构的影响

Effects of sacubitril valsartan combined with nicorandil on arterial stiffness and ventricular remodeling in patients with coronary heart disease

目的探讨沙库巴曲缬沙坦联合尼可地尔对冠心病患者大动脉僵硬度及心室重构的影响。方法选取2021年4月至2022年4月收治的80例冠心病患者为研究对象,将其随机分为对照组和观察组,各40例。对照组采用尼可地尔治疗,观察组采用沙库巴曲缬沙坦联合尼可地尔治疗。比较两组的治疗效果。结果观察组的治疗总有效率高于对照组(P<0.05)。治疗后,观察组的颈股脉搏波传导速度(cfPWV)、臂踝脉搏波传导速度(baPWV)低于对照组,踝肱指数(ABI)高于对照组(P<0.05)。治疗后,观察组的N端脑利钠肽前体(NT-proBNP)、同型半胱氨酸(Hcy)、肌钙蛋白I(cTnI)水平低于对照组(P<0.05)。治疗后,观察组的微小RNA-335-5p(miR-335-5p)、微小RNA-126(miR-126)表达水平高于对照组(P<0.05)。结论沙库巴曲缬沙坦联合尼可地尔治疗冠心病可提高治疗效果,减轻大动脉僵硬程度,改善心室重构,调节miR-335-5p、miR-126表达水平,值得推广。

Objective To explore the effects of sacubitril valsartan combined with nicorandil on arterial stiffness and ventricular remodeling in patients with coronary heart disease.Methods A total of 80 patients with coronary heart disease admitted from April 2021 to April 2022 were selected as the study objects and randomly divided into control group and observation group,with 40 cases in each group.The control group was treated with nicorandil,and the observation group was treated with sacubitril valsartan combined with nicorandil.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the carotid-femoral pulse wave velocity(cfPWV)and brachial-ankle pulse wave velocity(baPWV)in the observation group were lower than those in the control group,and the ankle brachial index(ABI)was higher than that in the control group(P<0.05).After treatment,the levels of N-terminal pro-brain natriuretic peptide(NT-proBNP),homocysteine(Hcy)and cardiac troponin I(cTnI)in the observation group were lower than those in the control group(P<0.05).After treatment,the microRNA-335-5p(miR-335-5p)and microRNA-126(miR-126)expression levels in the observation group were higher than those in the control group(P<0.05).Conclusion Sacubitril valsartan combined with nicorandil in the treatment of coronary heart disease can improve the therapeutic effect,reduce the degree of arterial stiffness,improve ventricular remodeling,and regulate the expression levels of miR-335-5p and miR-126,which is worthy of promotion.