短肽型营养制剂治疗重症急性胰腺炎的效果及对ARDS、MODS发生率的影响

Effect of short peptide nutrition preparation in the treatment of severe acute pancreatitis and its influences on the incidences of ARDS and MODS

目的探讨短肽型营养制剂治疗重症急性胰腺炎(SAP)的效果及对急性呼吸窘迫综合征(ARDS)、多器官功能障碍(MODS)发生率的影响。方法选取2019年7月至2020年9月我院收治的60例SAP患者作为研究对象,根据治疗方法将其分为对照组和观察组,各30例。两组患者均接受常规治疗,对照组在此基础上加肠外营养支持治疗,观察组在对照组的基础上加短肽型营养制剂肠内营养支持治疗。比较两组的治疗效果。结果治疗后,观察组的血红蛋白(Hb)、总蛋白(TP)、白蛋白(ALB)、前白蛋白(PA)水平高于对照组(P<0.05)。治疗后,观察组的内毒素、D-乳酸、二胺氧化酶、血淀粉酶水平低于对照组(P<0.05)。治疗后,观察组的C-反应蛋白(CRP)、高迁移率族蛋白B1(HMGB1)、热休克蛋白70(HSP-70)、人可溶性细胞间黏附分子-1(sICAM-1)水平低于对照组(P<0.05)。观察组的ARDS、MODS发生率低于对照组(P<0.05)。结论短肽型营养制剂治疗SAP的效果显著,能够改善患者的肠黏膜功能,抑制炎症因子表达,降低ARDS、MODS发生率,提高患者的生活质量。

Objective To explore the effect of short peptide nutrition preparation in the treatment of severe acute pancreatitis(SAP)and its influences on the incidences of acute respiratory distress syndrome(ARDS)and multiple organ dysfunction syndrome(MODS).Methods A total of 60 patients with SAP admitted in our hospital from July 2019 to September 2020 were selected as the study subjects.According to the treatment methods,the patients were divided into control group and observation group,with 30 cases in each group.Both groups received routine treatment.The control group was treated with parenteral nutrition support on this basis,and the observation group was treated with short peptide nutrition preparation of enteral nutrition on the basis of the control group.The therapeutic effects of the two groups were compared.Results After treatment,the levels of hemoglobin(Hb),total protein(TP),albumin(ALB)and prealbumin(PA)in the observation group were higher than those in the control group(P<0.05).After treatment,the levels of endotoxin,D-lactic acid,diamine oxidase and blood amylase in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of C-reactive protein(CRP),high mobility group protein B1(HMGB1),heat shock protein 70(HSP-70)and human soluble intercellular adhesion molecule-1(sICAM-1)in the observation group were lower than those in the control group(P<0.05).The incidences of ARDS and MODS in the observation group were lower than those in the control group(P<0.05).Conclusion Short peptide nutrition preparation has a significant effect in the treatment of SAP,which can improve the intestinal mucosal function of patients,inhibit the expression of inflammatory factors,reduce the incidences of ARDS and MODS,and improve the quality of life of patients.