肢端肥大症发病机制的研究进展

Research progress on the pathogenesis of acromegaly

肢端肥大症是一种罕见的内分泌疾病,超过95%的患者是由散发性分泌生长激素(GH)的垂体腺瘤引起,异位GH分泌瘤、促生长激素释放激素(GHRH)分泌瘤导致的肢端肥大症所占比例<5%。随着分子生物学等学科的迅速发展,人们对肢端肥大症发病机制的认识已有很大的变化。本文从散发性肢端肥大症、异位肢端肥大症、家族性肢端肥大症、肢端肥大症中的miRNA等方面对肢端肥大症发病机制研究的新进展进行综述,探讨未来肢端肥大症基础研究的可能方向。

Acromegaly is a rare endocrine disease,with over 95%of cases caused by sporadic growth hormone(GH)-secreting pituitary adenom as.The proportion of acrom egaly caused by ectopic GH-secreting pituitary adenomas and GH-releasing hormone(GHRH)-secreting pituitary adenomas is less than 5%.With the rapid development of disciplines such as molecular biology,people’s understanding of the pathogenesis of acromegaly has undergone significant changes.This article reviews the new progress in the pathogenesis of acromegaly from the perspectives of sporadic acromegaly,ectopic acromegaly,familial acromegaly,and miRNA in acromegaly,and explores possible directions for future basic research on acromegaly.