保妇康栓联合宫颈锥切术治疗宫颈上皮内瘤变Ⅲ级合并人乳头瘤病毒感染患者的效果

Effects of Baofukang suppository combined with cervical conization in treatment of patients with cervical intraepithelial neoplasia grade III complicated with human papillomavirus infection

目的:观察保妇康栓联合宫颈锥切术治疗宫颈上皮内瘤病变(CIN)Ⅲ级合并人乳头瘤病毒(HPV)感染患者的效果。方法:选取2021年9月至2022年9月该院收治的90例CINⅢ级合并HPV感染患者进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各45例。对照组行宫颈锥切术治疗,观察组在对照组基础上联合保妇康栓治疗,两组治疗后均随访6个月。比较两组临床疗效、临床指标(接触性出血停止时间、阴道分泌物正常时间、创面愈合时间)水平、治疗前后炎性因子[超敏C反应蛋白(hs-CRP)、白细胞介素-10(IL-10)、白细胞介素-6(IL-6)]水平和并发症/不良反应发生率。结果:观察组治疗总有效率为97.78%(44/45),高于对照组的77.78%(35/45),差异有统计学意义(P<0.05);观察组接触性出血停止时间、阴道分泌物正常时间、创面愈合时间均短于对照组,差异有统计学意义(P<0.05);治疗后,观察组hs-CRP、IL-10、IL-6水平均低于对照组,差异有统计学意义(P<0.05);两组并发症/不良反应发生率比较,差异无统计学意义(P>0.05)。结论:保妇康栓联合宫颈锥切术治疗CINⅢ级合并HPV感染患者可提高治疗总有效率,改善临床指标,降低炎性因子水平,效果优于单纯宫颈锥切术治疗。

Objective:To observe effects of Baofukang suppository combined with cervical conization in treatment of patients with cervical intraepithelial neoplasia(CIN)grade III combined with human papillomavirus(HPV)infection.Methods:A prospective study was conducted on 90 patients with CIN grade III and HPV infection admitted to the hospital from September 2021 to September 2022.They were divided into control group and observation group according to the random number table method,45 cases in each.The control group was treated with cervical conization,while the observation group was treated with Baofukang suppository on the basis of that of the control group.Both groups were followed up for 6 months after the treatment.The clinical efficacy,the clinical indicators(contact bleeding stop time,normal vaginal secretion time,wound healing time)levels,the inflammatory factors[high-sensitivity C-reactive protein(hs-CRP),interleukin-10(IL-10),interleukin-6(IL-6)]levels before and after the treatment,and the incidence of complications/adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was 97.78%(44/45),which was higher than 77.78%(35/45)in the control group,and the difference was statistically significant(P<0.05).The contact bleeding stop time,the normal vaginal secretion time and the wound healing time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of hs-CRP,IL-10 and IL-6 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of complications/adverse reactions between the two groups(P>0.05).Conclusions:Baofukang suppository combined with cervical conization in the treatment of the CIN grade III patients with HPV infection can improve the total effective rate of treatment and the clinical indicators,reduce the levels of inflammatory factors.Moreover,it is superior to single cervical conization.