D-D、CA19-9、CEA水平联合检测在胃肠恶性肿瘤诊断中的价值

Value of combined detection of D-D,CA19-9 and CEA levels in diagnosis of gastrointestinal malignant tumors

目的:探讨D-二聚体(D-D)、糖类抗原19-9(CA19-9)、癌胚抗原(CEA)水平联合检测在胃肠恶性肿瘤诊断中的价值。方法:回顾性分析2021年2月至2023年2月该院收治的60例胃肠恶性肿瘤患者的临床资料,设为恶性肿瘤组,另选取同期60名健康体检者设为健康对照组。比较两组D-D、CA19-9、CEA水平及其阳性率,分析D-D、CA19-9、CEA水平单项及联合检测在胃肠恶性肿瘤诊断中的价值。结果:恶性肿瘤组D-D、CA19-9、CEA水平均高于健康对照组,差异有统计学意义(P<0.05);恶性肿瘤组D-D、CA19-9、CEA阳性率分别为51.67%、56.67%、65.00%,均高于健康对照组的8.33%、5.00%、10.00%,差异有统计学意义(P<0.05);ROC曲线分析结果显示,D-D、CA19-9、CEA水平单项及联合检测诊断胃肠恶性肿瘤的曲线下面积分别为0.806、0.852、0.846、0.935,联合检测的诊断价值最高。结论:D-D、CA19-9、CEA水平联合检测在胃肠恶性肿瘤诊断中的价值高于三者单项检测。

Objective:To investigate value of combined detection of D-dimer(D-D),carbohydrate antigen 19-9(CA19-9)and carcinoembryonic antigen(CEA)levels in diagnosis of gastrointestinal malignant tumors.Methods:The clinical data of 60 patients with gastrointestinal malignant tumors admitted to the hospital from February 2021 to February 2023 were retrospectively analyzed.They were set as the malignant tumor group.60 healthy physical examination people were selected as the healthy control group.The levels and the positive rates of D-D,CA19-9 and CEA were compared between the two groups.The value of single and combined detection of D-D,CA19-9 and CEA levels in the diagnosis of gastrointestinal malignant tumors was analyzed.Results:The levels of D-D,CA19-9 and CEA in the malignant tumor group were higher than those in the healthy control group,and the differences were statistically significant(P<0.05).The positive rates of D-D,CA19-9 and CEA in malignant tumor group were 51.67%,56.67%and 65.00%,separately,which were higher than 8.33%,5.00%and 10.00%in healthy control group,and the differences were statistically significant(P<0.05).The ROC curve showed that the areas under the curve of single and combined detection of D-D,CA19-9 and CEA levels in the diagnosis of gastrointestinal malignant tumors was 0.806,0.852,0.846 and 0.935,separately,and the value of combined detection was the highest.Conclusions:The value of combined detection of D-D,CA19-9 and CEA levels in the diagnosis of gastrointestinal malignant tumors is higher than that of single detection of the three.