噻托溴铵联合吸入激素治疗哮喘-慢性阻塞性肺疾病重叠综合征的效果分析

Analysis on Effect of Tiotropium Bromide Combined with Inhaled Corticosteroids in Treatment of Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome

目的:观察噻托溴铵联合吸入激素治疗哮喘-慢性阻塞性肺疾病重叠综合征(ACOS)的效果。方法:选取2021年12月—2023年1月肇庆市第一人民医院收治的120例ACOS患者作为研究对象,采用随机数字表法分为对照组与观察组,各60例。两组均行基础对症治疗,对照组在对症治疗基础上采用吸入激素治疗,观察组在对照组基础上使用噻托溴铵治疗。比较两组治疗效果。结果:治疗后,两组哮喘控制测试评分高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。两组慢性阻塞性肺疾病评估测试评分低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组第1秒用力呼气容积、呼气峰值流速、第1秒用力呼气容积占用力肺活量比值高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。观察组总有效率高于对照组,差异有统计学意义(P=0.023)。观察组不良反应发生率低于对照组,差异有统计学差异(P=0.040)。结论:ACOS患者采用噻托溴铵联合吸入激素治疗效果显著,能够有效缓解患者临床症状,改善肺功能,降低不良反应发生率。

Objective:To observe the effect of tiotropium bromide combined with inhaled corticosteroids in the treatment of asthma-chronic obstructive pulmonary disease overlap syndrome(ACOS).Methods:A total of 120 ACOS patients who underwent treatment in the First People's Hospital of Zhaoqing from December 2021 to January 2023 were selected as the study subjects.They were divided into control group and observation group according to random number table method,with 60 cases in each group.Both groups received basic symptomatic treatment.The control group received inhaled corticosteroids on the basis of symptomatic treatment,and the observation group was treated with tiotropium bromide on the basis of control group.The treatment effects were compared between two groups.Results:After treatment,the asthma control test score in the two groups was higher than that before treatment,and the observation group was higher than the control group,and the difference was statistically significant(P<0.05).The chronic obstructive pulmonary disease assessment test score in the two groups was lower than that before treatment,and the observation group was lower than the control group,and the difference was statistically significant(P<0.05).After treatment,the forced expiratory volume in 1 second,the peak expiratory flow and the percentage of forced expiratory volume in 1 second to the forced vital capacity in the two groups were higher than those before treatment,and the observation group was higher than the control group,and the difference was statistically significant(P<0.05).The total effective rate in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.023).The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P=0.040).Conclusion:The tiotropium bromide combined with inhaled corticosteroids is effective in the treatment of ACOS patients,and can effectively relieve clinical symptoms,ameliorate lung function,and reduce the incidence of adverse reactions.